Neuravi Thromboembolic Initiative

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The Science of Clot

The complex nature of clot can complicate therapeutic intervention.
No two occlusions are alike – clots that cause a stroke can have a variety of compositions and properties. The NTI is Neuravi’s commitment to advance the treatment of stroke through interdisciplinary collaboration and investment in clot and occlusion research.

  • Modeling Diverse Clots that Cause Stroke

    Clots that cause stroke can come from numerous sources in the body, and they differ in composition, age, and morphology. Neuravi has developed protocols to create a wide range of clot analogs that reflect clinical clots, in order to better understand these challenges in treating ischemic stroke.

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    Staining of four different clot types (x20 magnification). MSB stained fibrin red and erythrocytes yellow:

    Duffy S, et al. J NeuroIntervent Surg 2016;0:1–7.

  • Advancing the Understanding of Occlusion Dynamics

    Occlusion formation is influenced by many variables, including clot type, clot geometry, vessel anatomy and flow conditions. Understanding the mechanisms of occlusion formation can provide insights into optimal clot removal technique. A couple of examples of the many occlusions modeled and studied by Neuravi are shown below.

    Extrusion Mechanism

    Folding Mechanism

    Friction Mechanism

  • Advancing the Understanding of Clot-Device Interaction

    Multiple clot properties change with clot-device interaction. One example is that as a clot undergoes compression, the coefficient of friction and resistance to retrieval increases.

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    NTI research collaborations are exploring an extensive set of
    properties and implications related to clot-device interaction.